Los Angeles Angels at Los Angeles Dodgers odds, picks and predictions (2025)

The Los Angeles Angels (29-45) and the Los Angeles Dodgers (47-30) open a 3-game interleague series on Friday at Dodger Stadium. First pitch is scheduled for 10:10 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’slines around the Angels vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Dodgers won 4-0 in 2023

The Dodgers have won 10 consecutive meetings in this series, with the Angels last winning Aug. 6, 2021, in a game LHP Patrick Sandoval started. The Halos won 4-3 on the day as a moderate underdog (+195) as the Under (8) cashed. Starting opposite Sandoval was LHP David Price, so yeah, it’s been a while.

In the 10-game win streak, which includes a 4-game sweep last season by a combined 25-9 margin, the Dodgers have allowed 3 or fewer runs in 8 of the 10 outings. In the past 9 games, they have allowed 2 or fewer runs 7 times.

The Angels have dropped the past 2 games, and 3 of the past 4 outings, and they were shut out 2-0 against the Milwaukee Brewers on Wednesday to wrap up that interleague series. Los Angeles is still a respectable 14-13 in interleague play.

The Dodgers have won 4 of the past 5 games, although they’re a mere 5-6 in the past 11 outings in front of the home fans since May 21. The Over has cashed in 3 of the past 4 outings, while the offense has averaged 7.8 runs per game (RPG) during the span.

Angels at Dodgers projected starters

LHP Patrick Sandovalvs. RHP Landon Knack

Sandoval (2-8, 5.24 ERA) makes his 16th start. He has a 1.50 WHIP, 3.8 BB/9 and 9.3 K/9 in 77 1/3 IP.

• Last start: No-decision, 5 IP, 3 ER, 8 H, 2 BB, 5 K in 4-3 road win vs. San Francisco Giants last Saturday
• 2024 road splits: 2-2, 4.46 ERA (34 1/3 IP, 17 ER), 1.49 WHIP, .258 opponents’ batting average (OBA), 3 HR, 17 BB, 35 K in 7 starts
• Career vs. Dodgers: 0-3, 5.40 ERA (21 2/3 IP, 13 ER), 1.66 WHIP, 7.5 K/9 in 4 starts and 1 relief appearance

Knack (1-1, 2.61 ERA) makes his 5th start. He has a 0.97 WHIP, 2.6 BB/9 and 7.0 K/9 in 20 2/3 IP.

• Last start: No-decision, 4 2/3 IP, 1 ER, 3 H, 1 BB, 5 K in 3-2 home win in 10 innings vs. Cincinnati Reds May 19
• 2024 home splits: 0-1, 2.79 ERA (9 2/3 IP, 3 ER), 0.93 WHIP, .206 OBA, 1 HR, 2 BB, 9 K in 2 starts

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Angels at Dodgers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:05 p.m. ET.

• Moneyline (ML): Angels +150 (bet $100 to win $150) | Dodgers -185 (bet $185 to win $100)
• Run line (RL)/Against the spread (ATS): Angels +1.5 (-135) | Dodgers -1.5 (+110)
• Over/Under (O/U): 8.5 (O: -120 | U: +100)

Angels at Dodgers picks and predictions

Prediction

Dodgers 6, Angels 4

Moneyline

The Dodgers (-185) are a little too expensive despite their dominance in this series. They’ve won 10 consecutive meetings in this series, and that was when Shohei Ohtani was playing for the Angels (+150). Now, he is on their side, too, playing his 1st game against his former mates.

Ohtani, by the way, enters this game with at least 1 RBI in 5 straight games, totaling 9 in the span.

While it looks good that the Dodgers will win an 11th straight in this series, Sandoval was the starting pitcher the last time the Angels won in this series on Aug. 6, 2021.

PASS.

Run line/Against the spread

The DODGERS -1.5 (+110) are a better play in this interleague series opener on the run line, although there is obviously some risk. Backing Knack, who has just 4 career starts, comes with some risk. He hasn’t appeared in the majors in over a calendar month, too.

However, the Angels +1.5 (-135) are going through it, again, struggling to generate offense, and facing a Dodgers team with the best run differential in the NL (+108) won’t help.

Over/Under

OVER 8.5 (-120) is a little on the pricey side, but a solid play in this battle.

The Over has cashed in 3 of the past 4 games for the Dodgers, with the home team playing at least 5 runs in 4 consecutive outings. The pitching staff has been knocked around for 24 runs in the past 4 tries, too, although all of those games were played in the rarefied air of Coors Field.

While the Under is 3-1-1 in the past 5 games for the Angels, the Over is a healthy 9-3 across the past 12 outings on the road.

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